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PostDoc Charting the Lung Cell Atlas by single-cell profiling of the airway wall

DepartmentGroningen Research Institute of Asthma and COPD (GRIAC)
Work locationGroningen
Apply no later than11 March 2020

Working environment

The Human Cell Atlas (HCA) project is an international consortium aiming to identify all cell types and their molecular phenotypes in the human body through a combination of high-throughput single-cell genomic profiling and spatial mapping using multiplexed FISH or spatial transcriptomics. The Human Lung Cell Atlas is one of the flagship programs of the HCA and will serve as a critical reference for understanding the changes in cellular composition and states, and the cell-cell and cell-matrix interactions underlying chronic lung disease. Asthma is such a chronic respiratory disease with increasing prevalence. We have recently shown that single-cell RNA sequencing can elucidate the cellular and molecular mechanisms operating in asthma. Within the HCA-Lung we perform single cell RNA sequencing and multiplexed FISH analyses on bronchial biopsies obtained from both patients with asthma and healthy controls. We will isolate bronchial epithelial cells for further functional analysis in ex vivo 3D organoid cultures of primary bronchial epithelial cells.

Job description

Within the HCA-Lung activities, we have an opening for a PostDoc on the recently awarded discovAIR H2020 project, focused on the generation and analysis of single-cell RNA seq data of airway wall tissue, integration of these datasets with other levels of omics data (ATAC-Seq, CHIP-Seq, SNP genotypes) and charting cell-state transitions in real-time using an asthma-centric perturbation atlas of primary epithelial cells using in vitro 3D lung organoid culture models.

The project will be embedded within the Groningen Research Institute of Asthma and COPD (GRIAC), one of the 3 world’s leading translational research institutes in chronic respiratory disease. The project is embedded within the discovAIR H2020 project, coordinated by GRIAC scientists and part of the Human Cell Atlas consortium.

What do we need

The successful candidate will hold a recent PhD degree in Molecular Biology or Life Sciences, with a focus on lung biology or respiratory disease, and meets the following criteria:

  • Thorough background in molecular biology and bio-informatics, as evidenced by research experience and CV.
  • Team player with excellent communicative skills who can collaborate efficiently within a multidisciplinary research environment.
  • Strong motivation to perform cutting-edge research in a competitive, international research environment.
  • Clear interest in immunological and epithelial cell biological research.
  • Clear interest in functional genetics or genomics.
  • Track record of working in a translational research environment, interacting with a team of medical specialists, support staff, wet-lab scientists and data analysts.

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.

In case of specific professions a ‘Certificate of Good Conduct’ is required.

What do we offer

  • We offer a temporary contract for 2 years.
  • Your monthly gross salary will be a maximum of € 4.481,- (scale 10) based on a full-time basis (36.0 hours per week).
  • In addition, the UMCG will offer you 8% holiday pay, an 8.3% end-of-year bonus.
  • The terms of employment comply with the Collective Labour Agreement for Medical Centers (CAO-UMC).
  • Preferred starting date: as soon as possible.

More information
For further information, please contact:
Dr. Martijn C. Nawijn, Associate Professor, e-mail: Contact (for inquiries only, please do not use for applications)

Applying for a job

Please use the the digital application form at the bottom of this page - only these will be processed. You can apply until 11 March 2020.
Within half an hour after sending the digital application form you will receive an email- confirmation with further information.