Transplantation is the therapy of choice as treatment of end stage organ failure. During the last 30 years organ transplantation evolved from an experimental procedure to a common procedure. The growing demand for transplantable organs led to long waiting lists requiring expansion of the donor pool. While the typical donor 30 years ago was a healthy young donor, nowadays the typical donor is an older donor, with a history of diabetes, high blood pressure and other co-morbidities. The quality of the transplantable organs is therefore also poorer and it is logical that post-transplant function is lower.
During a transplant procedure several hazardous periods for the organ occurs. Cardiac arrest and brain death are causing injury in terms of cellular malfunction and activation of the immune system. Between retrieval and implantation the organ is devoid of blood supply leading to ischemic injury. Paradoxally, during the restoration of blood flow additional injury occurs due formation of oxygen radicals.
The section has a long lasting tradition in research aiming at improving organ quality. The research is focussing on
A. The impact of brain death and cardiac arrest on organ quality.
B. Improvement of preservation of donor organs between donation and implantation.
C. Improvement of short term outcome.
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