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Research technicians for the iPSC/CRISPR center

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DepartmentThe European Research Institute for the Biology of Ageing (ERIBA)
Work locationGroningen
Apply no later than15 December 2019

Working environment

ERIBA is a joint effort between the University Medical Center Groningen (UMCG) and the University of Groningen (RUG) in The Netherlands. With over 50,000 students, Groningen offers a vibrant academic community in a classic small-town setting of 200,000 inhabitants. Studies in ERIBA are focused on the molecular mechanisms of ageing and ageing-associated disease. For this, we have access to state-of-the-art-equipment and infrastructure including single cell DNA and RNA sequencing, CRISPR genome wide screens, flow cytometry, live cell imaging, mass spectrometry and bioinformatics.

One of the ERIBA-based research infrastructures is the RUG/UMCG iPSC/CRISPR center. The iPSC/CRISPR center is an expertise center and education hub for iPSC and CRISPR-related technologies. We generate induced pluripotent stem cells (iPSCs) and help implement protocols to differentiate iPSCs into various tissue types and 2D and 3D cultures. Furthermore, the iPSC/CRISPR center helps end-users to genetically engineer cell lines, primary cells and model organisms, including mice using CRISPR/Cas9 technology. Finally, we support functional genetic screens using genome-wide and targeted CRISPR libraries. The iPSC/CRISPR center is part of the ERIBA technology center, that furthermore encompasses the UMCG Research Sequencing Core, with whom we closely collaborate.

We are currently looking for 2-3 research technicians for the iPSC/CRISPR center to strengthen our team.

Job description

You have a BSc, MSc or PhD degree in Life Sciences (Molecular Biology, Biochemistry or Genetics) and extensive experience with tissue culture and various molecular biology techniques such as CRISPR genome engineering. You will join a team consisting of a project manager, 3-4 technicians and a bioinformatician who together form the iPSC/CRISPR team.

As a research technician at the iPSC/CRISPR center, you will assist in reprogramming primary human somatic cells into iPS cells, and in establishing differentiated cell progeny from these cultures. As we intend to automate part of these cultures, an affinity with tissue culture robotics is encouraged. Furthermore, you will be using CRISPR/Cas9 genome engineering in various cell types to engineer knockout and knock-in cell lines, including beyond state-of-the-art reporter cell lines. Extensive experience with at least one of these technologies (iPSC and/or CRISPR) is desirable but you will be expected to quickly become an expert on both.

In order to stay abreast of the latest technologies, you are inquisitive and willing to test new protocols as needed. At the same time, you will standardize newly implemented protocols into standard operating procedures to warrant a constant quality of our products. Finally, as you interact with many of our local and external customers, you have excellent communication skills as well as an entrepreneurial and customer-minded attitude.

What do we offer

All positions are initially for 1 year, with a possible extension.
The starting salary is dependent on your degree and experience and is scaled in 7 (max gross salary € 3.184, based on a full-time position). In addition, the UMCG will offer you 8% holiday pay and 8.3% end-of-year bonus. The conditions of employment comply with the Collective Labour Agreement of Medical Centers (CAO-UMC).

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.
In case of specific professions a ‘Certificate of Good Conduct’ is required.

More information
For more information about these vacancies you may contact:
Dr. F. Foijer, Team leader, ERIBA; email: Contact (do not use for applications)

Information about ERIBA: http://eriba.umcg.nl
Information about the iPSC/CRISPR center: http://eriba.umcg.nl/ipsc-crispr-facility/
Information about Groningen: http://portal.groningen.nl/en

How to apply
Full applications including a resume and a motivation letter will receive full consideration if received before 15 December 2019.

Please use the the digital application form at the bottom of this page - only these will be processed.
You can apply until 15 December 2019.
Within half an hour after sending the digital application form you will receive an email- confirmation with further information.