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Scientific Aims and Objectives

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Overall aim of the LifeLines Study is to unravel the interaction between genetic and environmental factors in the development of multifactorial diseases, their concurrent development in individuals and their complications as a complex trait.

Primary objectives are:

a. Which are the disease overriding risk factors which predict the development of a multifactorial disease during lifetime?
b. How are these universal risk factors modified, or what determines the effect of a universal risk factor in an individual?

Secondary aims:

Secondary aims include the assessment of the prevalence and incidence of multifactorial diseases, their risk factors and their treatment in individuals as well as in families. The burden of disease for the society will be quantified in terms of care needed, and total costs of care.

The LifeLines database contains questionnaire data, physical measurements and biological samples from different health examinations. More details on their content can be found in the LifeLines Protocols (see LifeLines Research Website below). Collaboration is encouraged as it helps to maximize the scientific value of the wealth of epidemiologic data made possible by the participation of more than 165,000 individuals in the LifeLines Cohort Study. Please see for more information the Lifelines Research Website below.