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Triglyceride-Rich Lipoprotein and LDL Particle Subfractions and their Association with Incident Type 2 Diabetes: The PREVEND Study

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28 July 2021

Sara Sokooti, Jose L. Flores-Guerrero, Hiddo J. L. Heerspink, Margery A. Connelly, Stephan J. L. Bakker & Robin P. F. Dullaart

It is known for decades that T2D is featured by abnormalities in circulating lipoproteins, comprising elevations in tri-glyceride-rich apolipoprotein B (apoB)-containing lipo-proteins and low levels of high density lipoproteins (HDL). Interestingly, recent studies have suggested that abnormalities in triglyceride-rich apolipoprotein B (apoB)-containing lipoproteins may precede insulin resistance, which in turn is a major risk factor for T2D development. Recently, a nuclear magnetic resonance (NMR) spectroscopy-based method was developed for quantifying triglyceride-rich lipoprotein (TRL) and LDL particle and subfraction concentrations in human plasma.
We explored the associations between TRL and LDL particle and subfraction concentrations with β-cell function taking account of insulin resistance. Moreover, we determined the associations of TRL and LDL particle and subfraction concentrations with incident T2D taking account of β-cell function and insulin resistance in various subgroups.
Given that little information is available on the role of circulating VLDL and LDL and their subfractions on β cell failure, our findings enhance current insight as to the role of TRL and LDL particle on ß-cell function modulation. Moreover, our findings highlight the relevance of lipoprotein subfraction measurement using a novel NMR platform-derived algorithm in assessing the association of lipoprotein characteristics with the risk of T2D development.

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