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HDL particle subspecies and their association with incident type 2 diabetes: the PREVEND study

10 February 2021

​Sara Sokooti, Jose L Flores-Guerrero, Lyanne M Kieneker, Hiddo JL Heerspink, Margert A Connelly, Stephan JL Bakker, Robin PF Dullaart

It is established that high-density lipoprotein cholesterol (HDL-C) is inversely associated with risk of developing type 2 diabetes (T2D) as described previously in different ethnic groups. However, HDL particles are heterogen​eous and vary in composition, size and function, which may lead to differential associations with incident T2D. While in previous size-based HDL particle analyses, lower levels of large HDL particles and higher levels of smaller HDL particles were more likely to be associated with insulin resistance and the development of T2D, associations of medium and small HDL particles with incident T2D have been inconsistently reported.

Newly developed nuclear magnetic resonance (NMR)-derived algorithm provides concentrations for seven HDL subspecies with increasing size from H1P to H7P. We aimed to investigate the association of HDL particle subspecies with incident T2D in the general population. We found that larger HDL size and higher H4P concentrations were inversely associated with T2D development, whereas H2P levels were positively associated with T2D development after multiple adjustments for relevant covariates.

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