Angelina Osipyan, Deng Chen, Frank J.Dekker
Epigenetics can be defined as heritable variations in gene expression without changing the DNA sequence itself. We found that epigenetic mechanisms are involved in the regulation of MIF-signaling and can be a target for drug discovery in MIF-related diseases. Altered expression of MIF and altered activity states of the connected pathways are linked to inflammatory diseases and cancer. Current studies show that the expression levels of MIF in neuroblastomas, breast cancer, and rheumatoid arthritis were significantly reduced after treatment with the histone deacetylase inhibitors (HDACis), thus supporting that it can reduce MIF expression levels. Based on our findings, therapeutic strategies targeted at epigenetic mechanisms have the potential to regulate MIF-mediated signaling in cancer and inflammation.
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