The aim of our clinical research program on mood and anxiety disorders is to improve patient outcomes by developing more effective interventions based on a better understanding of individual prognosis, disease subtypes and day-to-day symptom patterns. We do randomized clinical trials as well as clinical and epidemiological cohort studies. We develop more accurate monitoring devices to aid patient self-management and improve early recognition of relapse.
NEW-PRIDE is a randomized clinical trial investigating the neurocognitive working mechanisms of preventive cognitive therapy for preventing relapse.
Zelf-i (Self-management Intervention)
In the ZELF-i study, individuals with depressive complaints use a web application ('app') to gather information (and receive personalized feedback) on their own mood, thoughts, behaviors, and social context in the flow of daily life. The project aims to investigate the effectiveness and patient-experienced utility of ZELF-i as an add-on tool in routine clinical care.
In the Therap-i study, patients with complex depressive symptoms fill in a personalized electronic diary to collect information on mood, thoughts, behavior and context in daily life. Furthermore, they receive feedback on these collected data which will be collaboratively discussed between the patient, therapist and researcher. Collectively, this is named the “Therap-i module”. The study aims to investigate the effectiveness and patient-experienced utility of the Therap-i module as an add-on tool in clinical care. We hypothesize that the Therap-i module will contribute to decreased depressive symptoms via a more precise descriptive diagnosis, tailored treatment and increased self-insight, resulting in enduring increased self-management and better functional outcomes.
Time for a change: an out-of-the-box approach to unravel transitions in depression (TRANS-ID)
Complex dynamical systems show generic early warning signals (EWS) that indicate the approach of a critical transition in the system. The TRANS-ID project investigates whether such EWS also anticipate critical transitions in depression (and transdiagnostically) using individual time-series experiments.
Netherlands Study of Depression and Anxiety (NESDA)
NESDA is an ongoing multi-site naturalistic cohort study-to-study long term prognosis of anxiety, depression and their co-morbidity, in order to contribute to improved quality of care and prevention of chronicity.
TRacking Adolescents Individual Lives Survey (TRAILS)
TRAILS is an ongoing, multidisciplinary research project on the psychological, social and physical development of children towards adulthood. Nearly 2900 people participate, since their tenth year.
HowNutsAreTheDutch (Dutch: HoeGekIsNL)
HowNutsAreTheDutch is a large national crowdsourcing study designed to investigate multiple continuous mental health dimensions in a sample from the general population.
No fun no glory
No fun no glory project is a biopsychosocial investigation of how adolescents lose the ability to experience pleasure and may gain it back again. In this study, causes and characteristics of loss of pleasure will be investigated in the existing longitudinal cohort survey TRAILS (www.trails.nl) and a to-be-conducted large cross-sectional survey, while an intervention study will be set up to examine to what extent personalized lifestyle advices and thrill experiences can help to improve symptoms.
Adolescents at RIsk of Anxiety and Depression (ARIADNE)
ARIADNE is a prospective cohort study investigating the onset and course of depressive and anxiety disorders in offspring of patients who had received treatment for depressive or anxiety disorder.
LifeLines Cohort Study
Lifelines is a three-generation observational cohort and biobank designed to investigate universal risk factors and complex interactions between environmental, phenotypic and genomic factors in the development of chronic multifactorial diseases in a population-based sample.
ketamine study is a double blind placebo controlled RCT investigating the effects of oral ketamine versus placebo as add-on to regular antidepressant medication in 128 patients with treatment resistant depression.
Psilocybin study is a placebo controlled study on the effects and optimal dosing of psilocybin in patients who had sub optimal outcome of regular antidepressant treatment.
Netherlands And China (NAC) Twin City Study (with TianJin mental health center)
The aim of this study is to investigate the efficacy of N-AcetylCysteine (NAC) supplementation in patients with increased C-reactive protein values who did not remit during standard antidepressant treatment using a double-blind randomised placebo controlled design.
Effectiveness of chronotherapy
In this study, we evaluate the outcome of our chronotherapy treatment program for patients with mood disorders (depressive phase).
Across different studies, we investigate markers of underlying disease mechanisms related to stress, inflammation, autonomic functioning and neuroplasticity.
Seasonal affective disorder projects
On the seasonal affective disorder (SAD) outpatient clinic of the UCP, research projects are regularly carried out into the etiology of winter depression, the mechanisms of action of light therapy, and to improve the treatment.
Treating therapy resistant depression with Pulsed Electro Magnetic Fields (PEMF)
The PEMF study is a double blind placebo controlled RCT investigating the antidepressive effects of Pulsed Electromagnetic Fields in patients with treatment resistant Depression
SWITCH-BD in bipolar patients
In this study, patients with bipolar disorder are monitored using an actiwatch and ecological momentary assessment (EMA) with the aim to determine whether physiological changes may precede new episodes and thus deserve a role in signaling increased risk during maintenance treatment.