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Genomics for Infection Prevention

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​​Chairing Principal Investigator: Alex W. Friedrich

Other Principal Investigators: John RossenBhanu Sinha​Adriana Tami​ 

The research group “Genomics for Infection Prevention (GIP)” is embedded within the Department of Medical Microbiology and Infection Prevention which has a major task in protecting patients against infections, performing diagnostics of infections and advising for optimal antimicrobial therapy. 

Within GIP fundamental and translational research is done focusing on the prevention of healthcare-associated infections in the hyper-susceptible society (ageing&immunocompromised patients). Here, state of the art technologies are used for the development of personalized diagnostics, the understanding of spread and optimal treatment of infections.

We focus on infections of public health relevance, such as healthcare-associated infections (e.g. sepsis, device-associated infections, endocarditis and surgical site infections) caused by antibiotic resistance (Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Enterococci (VRE), Carbapenem resistant microorganisms (CRE) in the hospitals as well as zoonotic diseases (STEC/EHEC) and Vector-borne-disease (Dengue) in the community. We coordinate and participate in several large national and international as well as Dutch-German cross-border projects comprising microbiological prevalence studies, molecular population structure analysis, novel forms of network-based infection control, and host-virus/bacterium interactions using metagenomics approaches.

Finally, we want to understand the transmission dynamics, epidemic and pathogenic power of multi-resistant microorganisms (e.g. MRSA, VRE, CRE) in order to maintain our region free of life-threatening infections. We use interventional modelling and network-analysis to improve network-based infection control and the application of novel technologies (NGS, shot gun metagenomics) to develop hub&spoke infection control and diagnostic stewardship. We collaborate within Microbes in Health&Disease (MHD) with other research groups of our department and the UMCG (e.g. ICU, imaging, orthopaedics, surgery) as well as with partners from different sectors in the (eu)region and internationally. 

We participate actively in the Aletta Jacobs School of Public Health for the goal of developing novel cross-sectorial and preventive-economic approaches to maintain infections curable in the health-care community.​​​​