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Role of epigenetic regulation by histone acetylation in the induction of Atrial Fibrillation

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Title: Role of epigenetic regulation by histone acetylation in the induction of Atrial Fibrillation
Investigator:  D Zhang
Promotor: RH Henning
Co-promoter(es): BJJM Brundel
Summary:  Atrial Fibrillation (AF) is a persistent disease characterized by electrical, structural and contractile changes in myocytes, commonly denoted as remodeling. We observed AF to modulate activation of proteins involved in epigenetic regulation, such as CaMKII, HDAC and NFAT. CaMKII activates HDAC resulting in pathological gene expression, structural remodeling and contractile dysfunction. This project will study AF-induced epigenetic modifications govern myocyte remodeling and if pretreatment with a HDAC inhibitor can prevent the induction of AF. 
Financing:  Dutch Heart Foundation 2009B024, PhD student
Start: 1-06-2010
End: 1-06- 2014

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