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Role of cyclooxygenase signalling on vascular dysfunction in the metabolic syndrome.


Title:   Role of cyclooxygenase signalling on vascular dysfunction in the metabolic syndrome.
Investigator:  SW Landheer
Promotor: RH Henning
Co-promoter(es):  LE Deelman, JH Buikema
 Summary: It was observed that baseline involvement of COX-derived prostaglandins (PG’s) in endothelial (dys-)function (E(D)F) in intrarenal arteries predicted for the degree of renal damage development after 5/6 Nx such that higher contractile PG’s (in normal healthy individuals!) at baseline was correlated with increased future proteinuria. Unpublished studies showed that aortic EDF development in Zucker diabetic fatty rats with DM-2 importantly involved increased contractile PG’s (preliminary data SW Landheer). Recent literature regarding E(D)F in this field additionally highlights the (shift in the) role of PG’s in ageing and pathophysiological conditions, and the role of COX1 vs COX2 herein. Previous work of our group concomitantly highlighted the involvement of caveolae both in EF and myogenic constriction in vascular function, and alterations herein in chronic heart failure. The question addressed in the present project is whether altered vascular COX-signalling in MBS and DM-2 involves shifted COX-1 and/or -2 due to altered caveolar function in MBS and DM-2.
Financing: Junior Scientific Masterclass, MD/PhD bursary
Start: 1-10-2010
End: 1-10-2014


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