||This PhD program is directed at the identification of the kinomic key proteins underlying the induction of early myocyte remodeling during tachypacing and stretch. This knowledge will be very useful in the development of additional, novel interventions directed at counteracting the key proteins, resulting in prevention of early remodeling and conservation of the myocyte function.
Employment of in vitro cell-models for cardiac diseases will gain new insight into the interplay of the various factors involved in different aspects of early myocyte remodeling. A new cell-model system to study stretch induced myocyte remodeling is clinically highly relevant, since stretch is of interest as it occurs in the atrium during heart failure and hypertension which are the most frequent precursors of AF. Increasing knowledge on stretch induced remodeling may ultimately lead to prevention of AF