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Vitamin-D deficiency as a risk marker for renal and CV complications in the general population

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Title:  Vitamin-D deficiency as a risk marker for renal and CV complications in the general population
Investigators:  Hiddo Lambers Heerspink, Stephan Bakker, Ron Gansevoort 
Supervisor:  Dick de Zeeuw 
Summary:  The traditional role of Vitamin D is to maintain calcium homeostasis and bone mineralization. However, recent studies indicate that vitamin D may have pleiotropic effects that go beyond the musculoskeletal system. Studies in (transgenic) mice confirm that vitamin D depletion result in increased RAAS biosynthesis in both renal and cardiac tissue and leads to high blood pressure and cardiac and renal damage Recent cross-sectional studies have shown that vitamin D deficiency is common and is related to increased plasma renin activity, blood pressure, albuminuria,[3] and prevalent cardiovascular disease. However, it is unknown whether Vitamin D deficiency whether vitamin D deficiency is an (independent) risk marker for adverse renal/cardiovascular events in the general population. The aim of this project is to determine whether vitamin D is associated with increased risk of renal/cardiovascular events in the general population. 
Start: 1-01-2010 
End:  31-12-2014

Projects
The use of a multiple parameter response efficacy score to predict the effect of a drug on hard renal and cardiovascular
Diabetes Mellitus Treatment for Renal Insufficiency Consortium (DIAMETRIC) database 
System biology approach for discovery of biomarkers of renal disease progressioni in diabetes (SysKid)
PROVALID – prospective multinational cohort study in patients with type 2 diabetes treated in primary care
Vitamin-D deficiency as a risk marker for renal and CV complications in the general population
A novel approach of personalized medicine: considering multiple effects of a single drug
Optimal hard endpoints in clinical trials of renal disease progression
Albuminuria as surrogate endpoint in clinical trials
Individual therapy response to a sodium-glucose transport inhibitor
Involving patients in the assessment and evaluation of medication treatment
Groningen Initiative to Analyse Type-2 diabetes Treatment ( GIANTT )
The role of medication adherence in predicting treatment response and estimating cost-effectiveness of statin treatment
Pharmacogenetics and response to treatment of oral antidiabetics
Quality of prescribing: patient specific indicators that predict better outcomes in diabetes patients
Quality assessment of pharmacotherapy in patients with chronic kidney disease
Cost effectiveness of ACEi and ARBs on renal failure in diabetes patients
Drug information and risk communication in Africa
Regulatory Science Projects