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The role of medication adherence in predicting treatment response and estimating cost-effectiveness of statin treatment

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Title:   The role of medication adherence in predicting treatment response and estimating cost-effectiveness of statin treatment
Investigator(s):  Dianna de Vries 
Supervisor(s):  Eelko Hak, Petra Denig
Promotores:  Eelko Hak, Petra Denig, Maarten Postma
Summary:

Diabetes patients are at increased risk for developing cardiovascular disease. The use of statins is associated with a reduction in the risk of cardiovascular events in diabetes patients with and without previous cardiovascular events. To be effective, however, patients need to adhere to the advised dose regimens. The high adherence rates as accomplished in a clinical trial setting may in practice be lower which reduces the health and economic impact of such preventive medication. The aim of this project is to increase our knowledge about the impact of non-adherence to statin treatment and determine whether statin treatment is cost-effective in diabetes patients, taking non-adherence, baseline risk, and age into account. The following studies are planned:
Primary prevention of cardiovascular and cerebrovascular events with statins in diabetic patients: a meta-analysis.

  • Cost effectiveness of statins for primary prevention in newly diagnosed type 2 diabetes patients in the Netherlands.
  • Does a cardiovascular event change adherence to statin treatment in patients with type 2 diabetes? A matched cohort study using the IADB data.
  • Secondary prevention of cardiovascular and cerebrovascular events with low and high potent statins in diabetic patients: a meta-analysis.
  • Cost-effectiveness of statins for the prevention of cardiovascular events in type 2 diabetes, low versus high potent statins.
  • The relation between adherence and LDL cholesterol reduction for low and standard dose statin treatment: a cohort study using the GIANTT data.
Financing:  1e GS
Start:  1-3-2013
End: 1-3-2015

 

Projects
The use of a multiple parameter response efficacy score to predict the effect of a drug on hard renal and cardiovascular
Diabetes Mellitus Treatment for Renal Insufficiency Consortium (DIAMETRIC) database 
System biology approach for discovery of biomarkers of renal disease progressioni in diabetes (SysKid)
PROVALID – prospective multinational cohort study in patients with type 2 diabetes treated in primary care
Vitamin-D deficiency as a risk marker for renal and CV complications in the general population
A novel approach of personalized medicine: considering multiple effects of a single drug
Optimal hard endpoints in clinical trials of renal disease progression
Albuminuria as surrogate endpoint in clinical trials
Individual therapy response to a sodium-glucose transport inhibitor
Involving patients in the assessment and evaluation of medication treatment
Groningen Initiative to Analyse Type-2 diabetes Treatment ( GIANTT )
The role of medication adherence in predicting treatment response and estimating cost-effectiveness of statin treatment
Pharmacogenetics and response to treatment of oral antidiabetics
Quality of prescribing: patient specific indicators that predict better outcomes in diabetes patients
Quality assessment of pharmacotherapy in patients with chronic kidney disease
Cost effectiveness of ACEi and ARBs on renal failure in diabetes patients
Drug information and risk communication in Africa
Regulatory Science Projects