Diabetes patients are at increased risk for developing cardiovascular disease. The use of statins is associated with a reduction in the risk of cardiovascular events in diabetes patients with and without previous cardiovascular events. To be effective, however, patients need to adhere to the advised dose regimens. The high adherence rates as accomplished in a clinical trial setting may in practice be lower which reduces the health and economic impact of such preventive medication. The aim of this project is to increase our knowledge about the impact of non-adherence to statin treatment and determine whether statin treatment is cost-effective in diabetes patients, taking non-adherence, baseline risk, and age into account. The following studies are planned:
Primary prevention of cardiovascular and cerebrovascular events with statins in diabetic patients: a meta-analysis.
- Cost effectiveness of statins for primary prevention in newly diagnosed type 2 diabetes patients in the Netherlands.
- Does a cardiovascular event change adherence to statin treatment in patients with type 2 diabetes? A matched cohort study using the IADB data.
- Secondary prevention of cardiovascular and cerebrovascular events with low and high potent statins in diabetic patients: a meta-analysis.
- Cost-effectiveness of statins for the prevention of cardiovascular events in type 2 diabetes, low versus high potent statins.
- The relation between adherence and LDL cholesterol reduction for low and standard dose statin treatment: a cohort study using the GIANTT data.