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Cost effectiveness of ACEi and ARBs on renal failure in diabetes patients

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Title:   Cost effectiveness of ACEi and ARBs on renal failure in diabetes patients
Investigator(s):  Yunyu Huang
Supervisor:  Jaco Voorham
Promoter:  Floor Haaijer-Ruskamp; Maarten Postma
Summary:  Cost effectiveness of drug treatment is primarily based on RCTs. However, in real life different patients are treated, and patients may behave differently in their use of drugs then in RCTs. In this project the effectiveness of ACEi and ARBs on renal failure in diabetes patients is analysed using a comparative effectiveness model in a population of 20000 diabetes patients in general practice (GIANTT), and mixed effect models. The results of these analysis will be used in assessing cost effectiveness and/ or budget impact.
Financing:  Bernouilli Grant
Sponsor:  UMCG
Start: 2011
End: 2015

 

Projects
The use of a multiple parameter response efficacy score to predict the effect of a drug on hard renal and cardiovascular
Diabetes Mellitus Treatment for Renal Insufficiency Consortium (DIAMETRIC) database 
System biology approach for discovery of biomarkers of renal disease progressioni in diabetes (SysKid)
PROVALID – prospective multinational cohort study in patients with type 2 diabetes treated in primary care
Vitamin-D deficiency as a risk marker for renal and CV complications in the general population
A novel approach of personalized medicine: considering multiple effects of a single drug
Optimal hard endpoints in clinical trials of renal disease progression
Albuminuria as surrogate endpoint in clinical trials
Individual therapy response to a sodium-glucose transport inhibitor
Involving patients in the assessment and evaluation of medication treatment
Groningen Initiative to Analyse Type-2 diabetes Treatment ( GIANTT )
The role of medication adherence in predicting treatment response and estimating cost-effectiveness of statin treatment
Pharmacogenetics and response to treatment of oral antidiabetics
Quality of prescribing: patient specific indicators that predict better outcomes in diabetes patients
Quality assessment of pharmacotherapy in patients with chronic kidney disease
Cost effectiveness of ACEi and ARBs on renal failure in diabetes patients
Drug information and risk communication in Africa
Regulatory Science Projects