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Albuminuria as surrogate endpoint in clinical trials

Title:   Albuminuria as surrogate endpoint in clinical trials
Investigator:  Tobias Kropelin
Supervisor:  Hiddo Lambers Heerspink, 
Promotor:  Dick de Zeeuw
Summary:   The presence of small amounts of albumin in the urine is one of the earliest signs of kidney damage and heralds a poor prognosis for renal and cardiovascular disease. Since albuminuria is such an important indicator of future renal and cardiovascular events, there is increased interest to test the effects of novel drugs on albuminuria. The rationale is that when one lowers albuminuria in the short-term one will provide long-term renal (and cardiovascular protection). Indeed previous studies have used albuminuria as a surrogate endpoint to replace hard renal and cardiovascular endpoints (such as dialysis or CV-death). However, there is persistent uncertainty how to optimally use albuminuria as surrogate endpoint in clinical drug trials. For example it is unknown how often urine for albuminuria assessment should be collected. The aim of this PhD project is to conduct a series of empirical studies to optimize the use of albuminuria as a surrogate for hard renal endpoints in nephrology and cardiovascular trials 
Financing:  UMCG 
Start:  01-09-2012 
End: 01-09-2015
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