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Publications 2016


  1. Akkerman OW, Odish OF, Bolhuis MS, de Lange WC, Kremer HP, Luijckx GJ, van der Werf TS, Alffenaar JW. Pharmacokinetics of Bedaquiline in Cerebrospinal Fluid and Serum in Multidrug-Resistant Tuberculous Meningitis. Clin Infect Dis. 2016 Feb 15;62(4):523-4. doi: 10.1093/cid/civ921. Epub 2015 Nov 3. PubMed PMID: 26534926.
  2. Akkerman OW, van Hateren K, Koster RA, Luijckx GJ, van der Werf TS, Alffenaar  JW. Reply to Verhaeghe et al. Clin Infect Dis. 2016 Jul 1;63(1):146-7. doi: 10.1093/cid/ciw165. Epub 2016 Mar 29. PubMed PMID: 27025830.
  3. Alffenaar JC, Akkerman OW, Anthony RM, Tiberi S, Heysell S, Grobusch MP, Cobelens FG, Van Soolingen D. Individualizing management of extensively drug-resistant tuberculosis: diagnostics, treatment, and biomarkers. Expert Rev Anti Infect Ther. 2017 Jan;15(1):11-21. PubMed PMID: 27762157.
  4. Alffenaar JC, Akkerman OW, van Hest R. Statin Adjunctive Therapy for Tuberculosis Treatment. Antimicrob Agents Chemother. 2016 Oct 21;60(11):7004. doi: 10.1128/AAC.01836-16. PubMed PMID: 28045667; PubMed Central PMCID: PMC5075134.
  5. Alsaad N, Dijkstra JA, Akkerman OW, de Lange WC, van Soolingen D, Kosterink JG, van der Werf TS, Alffenaar JW. Pharmacokinetic Evaluation of Sulfamethoxazole at 800 Milligrams Once Daily in the Treatment of Tuberculosis. Antimicrob Agents Chemother. 2016 Jun 20;60(7):3942-7. doi: 10.1128/AAC.02175-15. Print 2016 Jul. PubMed PMID: 27067336; PubMed Central PMCID: PMC4914613.
  6. Berm E, Kok R, Hak E, Wilffert B. Relation between CYP2D6 Genotype, Phenotype and Therapeutic Drug Concentrations among Nortriptyline and Venlafaxine Users in  Old Age Psychiatry. Pharmacopsychiatry. 2016 Sep;49(5):186-190. PubMed PMID: 27101231.
  7. Berm EJ, Gout-Zwart JJ, Luttjeboer J, Wilffert B, Postma MJ. A Model Based Cost-Effectiveness Analysis of Routine Genotyping for CYP2D6 among Older, Depressed Inpatients Starting Nortriptyline Pharmacotherapy. PLoS One. 2016 Dec 29;11(12):e0169065. doi: 10.1371/journal.pone.0169065. PubMed PMID: 28033366.
  8. Berm EJ, Looff Md, Wilffert B, Boersma C, Annemans L, Vegter S, Boven JF, Postma MJ. Economic Evaluations of Pharmacogenetic and Pharmacogenomic Screening  Tests: A Systematic Review. Second Update of the Literature. PLoS One. 2016 Jan 11;11(1):e0146262. doi: 10.1371/journal.pone.0146262. eCollection 2016. PubMed PMID: 26752539; PubMed Central PMCID: PMC4709231.
  9. Berm EJ, Odigie B, Bijlsma MJ, Wilffert B, Touw DJ, Maring JG. A clinical validation study for application of DBS in therapeutic drug monitoring of antidepressants. Bioanalysis. 2016 Mar;8(5):413-24. doi: 10.4155/bio.15.255. Epub 2016 Feb 19. PubMed PMID: 26893105.
  10. Blind E, de Graeff PA, Meurs I, Holtkamp F, Baczynska A, Janssen H. The European Medicines Agency's approval of proprotein convertase subtilisin/kexin type 9 inhibitors  Eur Heart J. 2016 Volume: 37  Issue: 6  Pages: 502-503.
  11. Bolhuis MS, Akkerman OW, Sturkenboom MG, de Lange WC, van der Werf TS, Alffenaar JC. Individualized treatment of multidrug-resistant tuberculosis using  therapeutic drug monitoring. Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S44-S45. doi: 10.1016/j.ijmyco.2016.07.003. PubMed PMID: 28043603.
  12. Bolhuis MS, Tiberi S, Sotgiu G, De Lorenzo S, Kosterink JG, van der Werf ​TS, Migliori GB, Alffenaar JW. Is there still room for therapeutic drug monitoring of linezolid in patients with tuberculosis? Eur Respir J. 2016 Apr;47(4):1288-90. doi: 10.1183/13993003.02185-2015. PubMed PMID: 27037319.
  13. Cattaneo D, Alffenaar JW, Neely M. Drug monitoring and individual dose optimization of antimicrobial drugs: oxazolidinones. Expert Opin Drug Metab Toxicol. 2016 May;12(5):533-44. doi: 10.1517/17425255.2016.1166204. Epub 2016 Mar 28. PubMed PMID: 26982718.
  14. Cho YY, Sidorenkov G, Denig P. Role of Patient and Practice Characteristics in Variance of Treatment Quality in Type 2 Diabetes between General Practices. PLoS  One. 2016 Nov 2;11(11):e0166012. doi: 10.1371/journal.pone.0166012. PubMed PMID:  27806107; PubMed Central PMCID: PMC5091743.
  15. Daud AN, Bergman JE, Kerstjens-Frederikse WS, Groen H, Wilffert B. The Risk of Congenital Heart Anomalies Following Prenatal Exposure to Serotonin Reuptake Inhibitors-Is Pharmacogenetics the Key? Int J Mol Sci. 2016 Aug 13;17(8). pii: E1333. doi: 10.3390/ijms17081333. Review. PubMed PMID: 27529241; PubMed Central PMCID: PMC5000730.
  16. de Boer SA, Hovinga-de Boer MC, Heerspink HJ, Lefrandt JD, van Roon AM, Lutgers HL, Glaudemans AW, Kamphuisen PW, Slart RH, Mulder DJ. Arterial Stiffness Is Positively Associated With 18F-fluorodeoxyglucose Positron Emission Tomography-Assessed Subclinical Vascular Inflammation in People With Early Type 2 Diabetes. Diabetes Care. 2016 Aug;39(8):1440-7. doi: 10.2337/dc16-0327. Epub 2016 Jun 8. PubMed PMID: 27281773.
  17. de Boer SA, Lefrandt JD, Petersen JF, Boersma HH, Mulder DJ, Hoogenberg K. The effects of GLP-1 analogues in obese, insulin-using type 2 diabetes in relation to eating behaviour. Int J Clin Pharm. 2016 Feb;38(1):144-51. doi: 10.1007/s11096-015-0219-8. Epub 2015 Nov 23. PubMed PMID: 26597956; PubMedCentral PMCID: PMC4733138. 
  18. de Vries FM, Voorham J, Hak E, Denig P. Prescribing patterns, adherence and LDL-cholesterol response of type 2 diabetes patients initiating statin on low-dose versus standard-dose treatment: a descriptive study. Int J Clin Pract. 2016 Jun;70(6):482-92. doi: 10.1111/ijcp.12806. Epub 2016 Apr 29. PubMed PMID: 27125890.
  19. de Zeeuw D, Heerspink HJ. Unmet need in diabetic nephropathy: failed drugs or trials? Lancet Diabetes Endocrinol. 2016 Aug;4(8):638-40. doi: 10.1016/S2213-8587(16)30045-6. Epub 2016 May 6. PubMed PMID: 27160545.
  20. Dekkers BG, Bakker M, van der Elst KC, Sturkenboom MG, Veringa A, Span LF, Alffenaar JC. Therapeutic Drug Monitoring of Posaconazole: an Update. Curr Fungal Infect Rep. 2016;10:51-61. Epub 2016 May 7. Review. PubMed PMID: 27358662; PubMed Central PMCID: PMC4896980.
  21. Dijkstra JA, Voerman AJ, Greijdanus B, Touw DJ, Alffenaar JW. Immunoassay Analysis of Kanamycin in Serum Using the Tobramycin Kit. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4646-51. doi: 10.1128/AAC.03025-15. Print 2016 Aug. PubMed PMID: 27185806; PubMed Central PMCID: PMC4958222.
  22. Dik JW, Poelman R, Friedrich AW, Panday PN, Lo-Ten-Foe JR, van Assen S, van Gemert-Pijnen JE, Niesters HG, Hendrix R, Sinha B. An integrated stewardship model: antimicrobial, infection prevention and diagnostic (AID). Future Microbiol. 2016;11(1):93-102. doi: 10.2217/fmb.15.99. Epub 2015 Sep 1. PubMed PMID: 26323589.
  23. Encalada Ventura MA, van Wanrooy MJ, Span LF, Rodgers MG, van den Heuvel ER,  Uges DR, van der Werf TS, Kosterink JG, Alffenaar JW. Longitudinal Analysis of the Effect of Inflammation on Voriconazole Trough Concentrations. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2727-31. doi: 10.1128/AAC.02830-15. Print 2016 May. PubMed PMID: 26883707; PubMed Central PMCID: PMC4862487.
  24. Fulcher G, Matthews DR, Perkovic V, de Zeeuw D, Mahaffey KW, Mathieu C, Woo V, Wysham C, Capuano G, Desai M, Shaw W, Vercruysse F, Meininger G, Neal B; CANVAS trial collaborative group. Efficacy and safety of canagliflozin when used  in conjunction with incretin-mimetic therapy in patients with type 2 diabetes. Diabetes Obes Metab. 2016 Jan;18(1):82-91. doi: 10.1111/dom.12589. Epub 2015 Dec  8. PubMed PMID: 26450639.
  25. Gareb B, Eissens AC, Kosterink JG, Frijlink HW. Development of a zero-order sustained-release tablet containing mesalazine and budesonide intended to treat the distal gastrointestinal tract in inflammatory bowel disease. Eur J Pharm Biopharm. 2016 Jun;103:32-42. doi: 0.1016/j.ejpb.2016.03.018. Epub 2016 Mar 19. PubMed PMID: 27000751.
  26. Geurts MM, Stewart RE, Brouwers JR, de Graeff PA, de Gier JJ. Implications of a clinical medication review and a pharmaceutical care plan of polypharmacy patients with a cardiovascular disorder. Int J Clin Pharm. 2016 Aug;38(4):808-15. doi: 10.1007/s11096-016-0281-x. Epub 2016 Apr 6. PubMed PMID: 27052212; PubMed Central PMCID: PMC4929171.
  27. Ghimire S, Bolhuis MS, Sturkenboom MG, Akkerman OW, de Lange WC, van der Werf TS, Alffenaar JW. Incorporating therapeutic drug monitoring into the World Health Organization hierarchy of tuberculosis diagnostics. Eur Respir J. 2016 Jun;47(6):1867-9. doi: 0.1183/13993003.00040-2016. Epub 2016 Mar 17. PubMed PMID: 26989104.
  28. Ghimire S, Van't Boveneind-Vrubleuskaya N, Akkerman OW, de Lange WC, van Soolingen D, Kosterink JG, van der Werf TS, Wilffert B, Touw DJ, Alffenaar JW. Pharmacokinetic/pharmacodynamic-based optimization of levofloxacin administration in the treatment of MDR-TB. J Antimicrob Chemother. 2016 Oct;71(10):2691-703. doi: 10.1093/jac/dkw164. Review. PubMed PMID: 27231277.
  29. Gracchi V, van den Belt SM, Küpers LK, Corpeleijn E, de Zeeuw D, Heerspink HJ. Prevalence and distribution of (micro)albuminuria in toddlers. Nephrol Dial Transplant. 2016 Oct;31(10):1686-92. doi: 10.1093/ndt/gfv407. PubMed PMID: 26705193.
  30. Hamidi Shishavan M, Bidadkosh A, Yazdani S, Lambooy S, van den Born J, Buikema H, Henning RH, Deelman LE. Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. PLoS One. 2016 Sep 1;11(9):e0162029.
  31. Hamidi Shishavan M, Bidadkosh A, Yazdani S, Lambooy S, van den Born J, Buikema H, Henning RH, Deelman LE. Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. PLoS One. 2016 Sep 1;11(9):e0162029. doi: 10.1371/journal.pone.0162029. PubMed PMID: 27583547; PubMed Central PMCID: PMC5008781.
  32. Han B, Poppinga WJ, Zuo H, Zuidhof AB, Bos IS, Smit M, Vogelaar P, Krenning G, Henning RH, Maarsingh H, Halayko AJ, van Vliet B, Stienstra S, Graaf AC, Meurs H, Schmidt M. The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease. Sci Rep. 2016 May 27;6:26928. doi: 10.1038/srep26928. PubMed PMID: 27229886; PubMed Central PMCID: PMC4882609.
  33. Heerspink HJ, De Zeeuw D. Novel anti-inflammatory drugs for the treatment of diabetic kidney disease. Diabetologia. 2016 Aug;59(8):1621-3. doi: 10.1007/s00125-016-4030-4. Epub 2016 Jun 23. Review. PubMed PMID: 27338625; PubMed Central PMCID: PMC4930464.
  34. Heerspink HJ, Johnsson E, Gause-Nilsson I, Cain VA, Sjöström CD. Dapagliflozin reduces albuminuria in patients with diabetes and hypertension receiving renin-angiotensin blockers. Diabetes Obes Metab. 2016 Jun;18(6):590-7. doi: 10.1111/dom.12654. PubMed PMID: 26936519; PubMed Central PMCID: PMC4850750.
  35. Heerspink HJ, Ninomiya T, Persson F, Brenner BM, Brunel P, Chaturvedi N, Desai AS, Haffner SM, Mcmurray JJ, Solomon SD, Pfeffer MA, Parving HH, de Zeeuw D. Is a reduction in albuminuria associated with renal and cardiovascular protection? A post hoc analysis of the ALTITUDE trial. Diabetes Obes Metab. 2016  Feb;18(2):169-77. doi: 10.1111/dom.12600. Epub 2016 Jan 13. PubMed PMID:26511599.
  36. Heerspink HJ, Perkins BA, Fitchett DH, Husain M, Cherney DZ. Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular  and Kidney Effects, Potential Mechanisms, and Clinical Applications. Circulation. 2016 Sep 6;134(10):752-72. doi: 10.1161/CIRCULATIONAHA.116.021887. Review. PubMed PMID: 27470878.
  37. Heerspink HJ, Persson F, Brenner BM, Chaturvedi N, Brunel P, McMurray JJ, Desai AS, Solomon SD, Pfeffer MA, Parving HH, de Zeeuw D. Renal outcomes with aliskiren in patients with type 2 diabetes: a prespecified secondary analysis of  the ALTITUDE randomised controlled trial. Lancet Diabetes Endocrinol. 2016 Apr;4(4):309-17. doi: 10.1016/S2213-8587(15)00469-6. Epub 2016 Jan 14. PubMed PMID: 26774608.
  38. Heetla HW, Proost JH, Molmans BH, Staal MJ, van Laar T. A pharmacokinetic-pharmacodynamic model for intrathecal baclofen in patients with severe spasticity. Br J Clin Pharmacol. 2016 Jan;81(1):101-12. PubMed PMID: 27099877; PubMed Central PMCID: PMC4693571.
  39. Hessels L, Oude Lansink A, Renes MH, van der Horst IC, Hoekstra M, Touw DJ, Nijsten MW. Postoperative fluid retention after heart surgery is accompanied by a strongly positive sodium balance and a negative potassium balance. Physiol Rep. 2016 May;4(10). pii: e12807. doi: 10.14814/phy2.12807. PubMed PMID: 27225629.
  40. Hofman S, Segers MM, Ghimire S, Bolhuis MS, Sturkenboom MG, Van Soolingen D,  Alffenaar JW. Emerging drugs and alternative possibilities in the treatment of tuberculosis. Expert Opin Emerg Drugs. 2016 Mar;21(1):103-16. doi: 10.1517/14728214.2016.1151000. Epub 2016 Feb 20. PubMed PMID: 26848966.
  41. Hoppentocht M, Akkerman OW, Hagedoorn P, Alffenaar JW, van der Werf TS, Kerstjens HA, Frijlink HW, de Boer AH. Tolerability and Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin Free Base in Non-Cystic Fibrosis Bronchiectasis Patients. PLoS One. 2016 Mar 9;11(3):e0149768. doi: 10.1371/journal.pone.0149768. eCollection 2016. PubMed PMID: 26959239; PubMed Central PMCID: PMC4784940.
  42. ​Huang Y, Haaijer-Ruskamp FM, Voorham J. Comparing the effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on renal function decline in diabetes. J Comp Eff Res. 2016 May;5(3):229-37. doi: 10.2217/cer.15.64. Epub 2016 Apr 22. PubMed PMID: 27102734.
  43. Huang Y, Voorham J, Haaijer-Ruskamp FM. Using primary care electronic health record data for comparative effectiveness research: experience of data quality assessment and preprocessing in The Netherlands. J Comp Eff Res. 2016 Jul;5(4):345-54. doi: 10.2217/cer-2015-0022. Epub 2016 Jun 27. PubMed PMID: 27346480.
  44. Hummels H, Bertholee D, van der Meer D, Smit JP, Wilffert B, Ter Horst P. The quality of lactation studies including antipsychotics. Eur J Clin Pharmacol. 2016 Dec;72(12):1417-1425. Review. PubMed PMID: 27558359.
  45. Huurneman LJ, Neely M, Veringa A, Docobo Pérez F, Ramos-Martin V, Tissing WJ, Alffenaar JW, Hope W. Pharmacodynamics of Voriconazole in Children: Further Steps along the Path to True Individualized Therapy. Antimicrob Agents Chemother. 2016  Mar 25;60(4):2336-42. doi: 10.1128/AAC.03023-15. Print 2016 Apr. PubMed PMID: 26833158; PubMed Central PMCID: PMC4808208.
  46. Ivanova SA, Loonen AJ, Bakker PR, Freidin MB, Ter Woerds NJ, Al Hadithy AF, Semke AV, Fedorenko OY, Brouwers JR, Bokhan NA, van Os J, van Harten PN, Wilffert B. Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations. SAGE Open Med. 2016 Apr 11;4:2050312116643673. doi: 10.1177/2050312116643673. eCollection 2016. PubMed PMID: 27127627; PubMed Central PMCID: PMC4834466.
  47. Jager NA, Wallis de Vries BM, Hillebrands JL, Harlaar NJ, Tio RA, Slart RH, van Dam GM, Boersma HH, Zeebregts CJ, Westra J. Distribution of Matrix Metalloproteinases in Human Atherosclerotic Carotid Plaques and Their Production  by Smooth Muscle Cells and Macrophage Subsets. Mol Imaging Biol. 2016 Apr;18(2):283-91. doi: 10.1007/s11307-015-0882-0. PubMed PMID: 26377769; PubMed Central PMCID: PMC4783451.
  48. Keyzer CA, de Jong MA, Fenna van Breda G, Vervloet MG, Laverman GD, Hemmelder M, Janssen WM, Lambers Heerspink HJ, Navis G, de Borst MH; Holland Nephrology Study (HONEST) Network. Vitamin D receptor activator and dietary sodium restriction to reduce residual urinary albumin excretion in chronic kidney disease (ViRTUE study): rationale and study protocol. Nephrol Dial Transplant. 2016 Jul;31(7):1081-7. doi: 10.1093/ndt/gfv033. Epub 2015 Mar 4. Review. PubMed PMID: 25744274.
  49. Koch M, de Jong JS, Glatz J, Symvoulidis P, Lamberts LE, Adams A, Kranendonk ME, Terwisscha van Scheltinga AG, Aichler M, Jansen L, de Vries J, Lub-de Hooge MN, Schröder CP, Jorritsma-Smit A, Linssen MD, de Boer E, van der Vegt B, Nagengast WB, Elias SG, Oliveira S, Witkamp A, Mali WP, van der Wall E, Garcia-Allende BP, Van Diest PJ, de Vries EG, Walch A, van Dam GM, Ntziachristos V. Threshold analysis and biodistribution of fluorescently labeled bevacizumab in human breast cancer. Cancer Res. 2016 Nov 22. pii: canres.1773.2016. [Epub ahead  of print] PubMed PMID: 27879266.
  50. Koedijk JB, Valk-Swinkels CG, Rijpstra TA, Touw DJ, Mulder PG, van der Voort PH, van 't Veer NE, van der Meer NJ. Pilot Study of the Pharmacokinetics of Cefotaxime in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy. Antimicrob Agents Chemother. 2016 May 23;60(6):3587-90. doi: 10.1128/AAC.02888-15. Print 2016 Jun. PubMed PMID: 27021325; PubMed Central PMCID: PMC4879359.
  51. Kröpelin TF, de Zeeuw D, Holtkamp FA, Packham DK, L Heerspink HJ. Individual long-term albuminuria exposure during angiotensin receptor blocker therapy is the optimal predictor for renal outcome. Nephrol Dial Transplant. 2016 Sep;31(9):1471-7. doi: 10.1093/ndt/gfv429. PubMed PMID: 26790449.
  52. Kröpelin TF, de Zeeuw D, Remuzzi G, Bilous R, Parving HH, Heerspink HJ. Determining the Optimal Protocol for Measuring an Albuminuria Class Transition in Clinical Trials in Diabetic Kidney Disease. J Am Soc Nephrol. 2016 Nov;27(11):3405-3412. PubMed PMID: 27056294; PubMed Central PMCID: PMC5084894.
  53. Kuypers MI, Lieshoud JR, van der Linden PD, Touw DJ, Deenik W, Boeke GM. A case of methemoglobinemia after ingestion of a chlorhexidine in alcohol solution in an alcohol-dependent patient. Clin Toxicol (Phila). 2016 Aug;54(7):604. doi: 10.1080/15563650.2016.1183778. Epub 2016 May 27. PubMed PMID: 27232424.
  54. Lamberts LE, Menke-van der Houven van Oordt CW, Ter Weele EJ, Bensch F, Smeenk MM, Voortman J, Hoekstra OS, Williams SP, Fine BM, Maslyar D, de Jong JR,  Gietema JA, Schröder CP, Bongaerts AH, Lub-de Hooge MN, Verheul HM, Sanabria Bohorquez SM, Glaudemans AW, de Vries EG. ImmunoPET with Anti-Mesothelin Antibody in Patients with Pancreatic and Ovarian Cancer before Anti-Mesothelin Antibody-Drug Conjugate Treatment. Clin Cancer Res. 2016 Apr 1;22(7):1642-52. doi: 10.1158/1078-0432.CCR-15-1272. Epub 2015 Nov 20. PubMed PMID: 26589435.
  55. Lamberts LE, Koch M, de Jong JS, Adams A, Glatz J, Kranendonk ME, Terwisscha van Scheltinga AG, Jansen L, de Vries J, Lub-de Hooge MN, Schroder CP, Jorritsma-Smit A, Linssen MD, de Boer E, van der Vegt B, Nagengast WB, Elias SG, Oliveira S, Witkamp A, Mali WP, van der Wall E, Van Diest PJ, de Vries EG, Ntziachristos V, van Dam GM. Tumor-specific uptake of fluorescent bevacizumab-IRDye800CW microdosing in patients with primary breast cancer: a phase I feasibility study. Clin Cancer Res. 2016 Nov 9. pii: clincanres.0437.2016. doi: 10.1158/1078-0432.CCR-16-0437. [Epub ahead of print] PubMed PMID: 28119364.
  56. Martono DP, Hak E, Lambers Heerspink H, Wilffert B, Denig P. Predictors of HbA1c levels in patients initiating metformin. Curr Med Res Opin. 2016 Dec;32(12):2021-2028. PubMed PMID: 27552675.
  57. Maurer JM, Hofman S, Schellekens RC, Tonnis WF, Dubois AO, Woerdenbag HJ, Hinrichs WL, Kosterink JG, Frijlink HW. Development and potential application of  an oral ColoPulse infliximab tablet with colon specific release: A feasibility study. Int J Pharm. 2016 May 30;505(1-2):175-86. doi: 10.1016/j.ijpharm.2016.03.027. Epub 2016 Mar 17. PubMed PMID: 26997425.
  58. Meems LM, Brouwers FP, Joosten MM, Lambers Heerspink HJ, de Zeeuw D, Bakker SJ, Gansevoort RT, van Gilst WH, van der Harst P, de Boer RA. Plasma calcidiol, calcitriol, and parathyroid hormone and risk of new onset heart failure in a population-based cohort study. ESC Heart Fail. 2016 Sep;3(3):189-197. PubMed PMID: 27818783; PubMed Central PMCID: PMC5074250.
  59. Meems LM, Mahmud H, Buikema H, Tost J, Michel S, Takens J, Verkaik-Schakel RN, Vreeswijk-Baudoin I, Mateo-Leach IV, van der Harst P, Plösch T, de Boer RA. Parental vitamin D deficiency during pregnancy is associated with increased blood pressure in offspring via Panx1 hypermethylation. Am J Physiol Heart Circ Physiol. 2016 Dec 1;311(6):H1459-H1469. doi: 10.1152/ajpheart.00141.2016. PubMed  PMID: 27769995.
  60. Mihaylova B, Schlackow I, Herrington W, Lozano-Kühne J, Kent S, Emberson J, Reith C, Haynes R, Cass A, Craig J, Gray A, Collins R, Landray MJ, Baigent C; SHARP Collaborative Group. Cost-effectiveness of Simvastatin plus Ezetimibe for Cardiovascular Prevention in CKD: Results of the Study of Heart and Renal Protection (SHARP). Am J Kidney Dis. 2016 Apr;67(4):576-84. doi: 10.1053/j.ajkd.2015.09.020. Epub 2015 Nov 18. PubMed PMID: 26597925; PubMed Central PMCID: PMC4801501.
  61. Mitrov-Winkelmolen L, van Buul-Gast MC, Swank DJ, Overdiek HW, van ​Schaik RH, Touw DJ. The Effect of Roux-en-Y Gastric Bypass Surgery in Morbidly Obese Patients on Pharmacokinetics of (Acetyl)Salicylic Acid and Omeprazole: the ERY-PAO Study. Obes Surg. 2016 Sep;26(9):2051-8. doi: 10.1007/s11695-016-2065-8.  PubMed PMID: 26797705.
  62. Nguyen TV, Cao TB, Akkerman OW, Tiberi S, Vu DH, Alffenaar JW. Bedaquiline as part of combination therapy in adults with pulmonary multi-drug resistant tuberculosis. Expert Rev Clin Pharmacol. 2016 Aug;9(8):1025-37. doi: 10.1080/17512433.2016.1200462. Epub 2016 Jun 27. PubMed PMID: 27322153.
  63. Olde Engberink RH, Heerspink HJ, de Zeeuw D, Vogt L. Blood pressure-lowering  effects of sulodexide depend on albuminuria severity: post hoc analysis of the sulodexide microalbuminuria and macroalbuminuria studies. Br J Clin Pharmacol. 2016 Nov;82(5):1351-1357. doi: 10.1111/bcp.13062. PubMed PMID: 27412828; PubMed Central PMCID: PMC5061782.
  64. Oosting SF, van Asselt SJ, Brouwers AH, Bongaerts AH, Steinberg JD, de Jong JR, Lub-de Hooge MN, van der Horst-Schrivers AN, Walenkamp AM, Hoving EW, Sluiter WJ, Zonnenberg BA, de Vries EG, Links TP. 89Zr-Bevacizumab PET Visualizes Disease Manifestations in Patients with von Hippel-Lindau Disease. J Nucl Med. 2016 Aug;57(8):1244-50. doi: 10.2967/jnumed.115.167643. Epub 2016 May 12. PubMed PMID: 27173161.
  65. Özyilmaz A, Boersma C, Visser ST, Postma MJ, de Jong-van den Berg LT, Lambers-Heerspink HJ, de Jong PE, Gansevoort RT. The association of albuminuria and high-sensitivity C-reactive protein with the efficacy of HMG-coenzyme A reductase inhibitors for cardiovascular event prevention. Eur J Prev Cardiol. 2016 May;23(8):847-55. doi: 10.1177/2047487315604310. Epub 2015 Sep 10. PubMed PMID: 26358992.
  66. Parving H-H, Lambers-Heerspink H, de Zeeuw D. Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes. N Engl J Med. 2016 Nov 3;375(18):1800-1. doi:  10.1056/NEJMc1611290. PubMed PMID: 28106974.
  67. Pena MJ, Heinzel A, Rossing P, Parving HH, Dallmann G, Rossing K, Andersen S, Mayer B, Heerspink HJ. Serum metabolites predict response to angiotensin II receptor blockers in patients with diabetes mellitus. J Transl Med. 2016 Jul 5;14(1):203. doi: 10.1186/s12967-016-0960-3. PubMed PMID: 27378474; PubMed Central PMCID: PMC4932762.
  68. Pena MJ, Mischak H, Heerspink HJ. Proteomics for prediction of disease progression and response to therapy in diabetic kidney disease. Diabetologia. 2016 Sep;59(9):1819-31. doi: 10.1007/s00125-016-4001-9. Epub 2016 Jun 25. Review. PubMed PMID: 27344310.
  69. Pena MJ, Mischak H, Heerspink HJ. Proteomics for prediction of disease progression and response to therapy in diabetic kidney disease. Diabetologia. 2016 Sep;59(9):1819-31. doi: 10.1007/s00125-016-4001-9. Review. PubMed PMID: 27344310; PubMed Central PMCID: PMC4969331.
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