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Cancan Qi: Multi-omics approaches to understand respiratory disease

Date: 15 September 2021
Time: 12:45
Location: Aula Academiegebouw Rijksuniversiteit Groningen
Address: Broerstraat 5 te Groningen
Promoter: prof dr G.H. Koppelman

​The main scope of this thesis is to improve our understanding of the biological mechanisms of allergic disease, in particular asthma and rhinitis, by applying multi-omics approaches. We collected multi-omics data from the genome, epigenome, bulk and single-cell transcriptome, and the exposome. By applying association and machine learning approaches, we investigated epigenetic mechanisms of the development of allergic disease, revealed cell-type specific molecular regulation of asthma risk variants, identified biomarkers of allergy, and provided a prediction tool for allergic disease.​​