Hongping Wan: Biolubrication enhancement for tissues and biomaterials. Biolubrication enhancement for tissues and biomaterials
Insufficient biolubrication leads to a drastic decrease in the quality of life associated with chronic pain, irritation, and restricted mobility. With the increasing aging population, more and more people worldwide suffer from lubrication dysfunction-related conditions like dry mouth, dry eye, and osteoarthritis, yielding severe discomfort.
Currently, the strategy used to restore biolubrication is to overwhelm the natural lubrication system with exogenous viscosity enhancer, which shows limited effect. To improve the quality of life of patients, it is urgent to develop a new strategy to enhance biolubrication.
This thesis presents a new approach of utilizing the existing impaired lubricants to repair the lubrication systems with the help of biopolymers. This thesis provides new insights in restoring the lubrication functionality in the living system.