The neurodegenerative branch of the Ageing Brain Unit addresses basic research on neurodegenerative processes and explores neuroregenerative approaches and novel imaging techniques to support long-term monitoring of neurodegenerative disease and putative repair processes. In addition, clinical aspects of neurodegenerative disease, including mild cognitive impairment, are investigated, as well as novel prevention and intervention strategies to promote optimal autonomy and well-being.
The neurodegenerative diseases Alzheimer disease, Multiple Sclerosis, Parkinson’s disease, Huntington and SCA diseases are major research topics. Basic aspects of underlying pathology are studied in neuronal cell cultures in vitro as well as in model organisms such as Drosophila melanogaster, C. elegans, and transgenic mice.
Protein misfolding neurodegenerative diseases, neuroinflammatory processes and vascular pathology are central topics in studies aimed at unravelling of the disease process and finding of disease modifiers that may have therapeutic relevance. Furthermore, elaborate research, including stem cell investigations, addresses neuroregenerative mechanisms. At the clinical level, aspects of cognitive deficits and dementia are addressed and novel treatments evaluated.