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The UMCG has a leading position in biobank research. There is a long tradition in both research with long-term cohorts of specific patient groups and in population-based studies. Well-known Groningen Biobank/cohort studies are LifeLines, Vlagtwedde-Vlaardingen, PREVEND, GIANTT, TRAILS, and Acutelines. Clinical biobanks have been given a boost by the participation of the UMCG in the Parelsnoer ​Institute (PSI) of the NFU.

Besides the different biobanks with large numbers of stored biomaterials and data, also a lot of expertise and experience is available in the UMCG on all methodological aspects of biobank research (e.g. research design, bioinformatics, bio-imaging, laboratory processes, statistics, on legal and regulatory affairs and on quality and privacy). In addition, the UMCG invested in facilities for biobank research, especially large-scale ICT facilities and long-term storage of biomaterials. In November 2012, the Board established the UMCG Biobank Regulations, that provide rules and guidelines for the collection, storage and use of human tissue and associated data from patients in the UMCG.

UMCG researchers are active on important positions in all national research data / biobank organisations, such as the nationwide Parelsnoer In​stitute (PSI), BBMRI-NL, NFU research IT "data4lifesciences", ZonMw data management projects, Dutch Tech Centre for Life Sciences (DTL), Surf Sara projects. Also in Europe, various UMCG researchers have influential positions in the field of biobank research as in the large FP7 biobank projects: BioSH​​aRE, coordinated by the UMCG and BBMRI LPC , with the UMCG as national representative. In addition, the UMCG is closely involved in Elixir, the European bioinformatics consortium.