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​​​​​​​​​​​​​Altogether, the Groningen MAECON members have (co)authored over 200 peer-reviewed scientific publications in the field of medication adherence. Topics span a wide range of methods ranging from measurement, to interventions and their cost-effectiveness. A selection of some key publications (MAECON members in bold) is provided below.​

Intervention studies  

SD Alfian, JF van Boven, R Abdulah, H Sukandar, P Denig, E Hak.
Effectiveness of a targeted and tailored pharmacist-led intervention to improve adherence to antihypertensive drugs among patients with type 2 diabetes in Indonesia: a cluster randomized controlled trial
British Journal of Clinical Pharmacology 2020; doi: 10.1111/bcp.14610. Online ahead of print.

SD Alfian, R Abdulah, P Denig, JF van Boven, E Hak.
Targeted and tailored pharmacist intervention to improve adherence to antihypertensive drugs among patients with type 2 diabetes in Indonesia: study protocol of a cluster randomized controlled trial
BMJ Open 2020; 10:e034507

IS Pradipta, D Houtsma, JF van Boven, JC Alffenaar, E Hak.
Interventions to improve medication adherence in tuberculosis patients: a systematic review of randomized controlled studies
npj Primary Care Respiratory Medicine 2020; 30:21

Linn AJ, van Dijk L, van Weert JCM, Gebeyehu BG, van Bodegraven AA, Smit EG.
Creating a synergy effect: A cluster randomized controlled trial testing the effect of a tailored multimedia intervention on patient outcomes.
Patient Educ Couns. 2018;101(8):1419-1426

Denig P, Schuling J, Haaijer-Ruskamp F, Voorham J.
Effects of a patient oriented decision aid for prioritising treatment goals in diabetes: pragmatic randomised controlled trial.
BMJ. 2014; 25;349:g5651

Nguyen T, Nguyen TH, Nguyen PT, Tran HT, Nguyen NV, Nguyen HQ, Ha BN, Pham TT, Taxis K.
Pharmacist-Led Intervention to Enhance Medication Adherence in Patients With Acute Coronary Syndrome in Vietnam: A Randomized Controlled Trial.
Front Pharmacol. 2018; 9:656

van Boven JF, Stuurman-Bieze AG, Hiddink EG, Postma MJ, Vegter S.
Medication monitoring and optimization: a targeted pharmacist program for effective and cost-effective improvement of chronic therapy adherence.
J Manag Care Spec Pharm. 2014;20(8):786-92

Vervloet M, van Dijk L, de Bakker DH, Souverein PC, Santen-Reestman J, van Vlijmen B, van Aarle MC, van der Hoek LS, Bouvy ML.
Short- and long-term effects of real-time medication monitoring with short message service (SMS) reminders for missed doses on the refill adherence of people with Type 2 diabetes: evidence from a randomized controlled trial.
Diabet Med. 2014;31(7):821-8

​Survey adherence measurement  

Linn AJ, van Weert JCM, Gebeyehu BG, Sanders R, Diviani N, Smit EG, van Dijk L.
Patients' Online Information-Seeking Behavior Throughout Treatment: The Impact on Medication Beliefs and Medication Adherence.
Health Commun. 2018; 27:1-8

de Vries ST, Keers JC, Visser R, de Zeeuw D, Haaijer-Ruskamp FM, Voorham J, Denig P.
Medication beliefs, treatment complexity, and non-adherence to different drug classes in patients with type 2 diabetes.
J Psychosom Res. 2014;76(2):134-8

Garcia-Marcos PW, Brand PL, Kaptein AA, Klok T.
Is the MARS questionnaire a reliable measure of medication adherence in childhood asthma?
J Asthma. 2016 Dec;53(10):1085-9

Database adherence measurement  

JF van Boven, M Koponen, S Lalic, J George, JS Bell, M Hew, J Ilomaki.
Trajectory analyses of adherence patterns in a real-life moderate to severe asthma population
Journal of Allergy & Clinical Immunology: In Practice 2020;8(6): 1961-1969

Holvast F, Wouters H, Hek K, Schellevis F, Oude Voshaar R, van Dijk L, Burger H, Verhaak P.
Non-adherence to cardiovascular drugs in older patients with depression: A population-based cohort study.
Int J Cardiol. 2019;274:366-371

Alfian SD, Denig P, Coelho A, Hak E.
Pharmacy-based predictors of non-adherence, non-persistence and reinitiation of antihypertensive drugs among patients on oral diabetes drugs in the Netherlands.
PLoS One. 2019 ;14(11):e0225390

Holvast F, Oude Voshaar RC, Wouters H, Hek K, Schellevis F, Burger H, Verhaak PFM.
Non-adherence to antidepressants among older patients with depression: a longitudinal cohort study in primary care.
Fam Pract. 2019;36(1):12-20

Alfian SD, Pradipta IS, Hak E, Denig P
.A systematic review finds inconsistency in the measures used to estimate adherence and persistence to multiple cardiometabolic medications.
J Clin Epidemiol. 2019;108:44-53

Alfian SD, Worawutputtapong P, Schuiling-Veninga CCM, van der Schans J, Bos JHJ, Hak E, Denig P.
Pharmacy-based predictors of non-persistence with and non-adherence to statin treatment among patients on oral diabetes medication in the Netherlands.
Curr Med Res Opin. 2018;34(6):1013-1019

de Vries FM, Voorham J, Hak E, Denig P.
Prescribing patterns, adherence and LDL-cholesterol response of type 2 diabetes patients initiating statin on low-dose versus standard-dose treatment: a descriptive study.
Int J Clin Pract. 2016;70(6):482-92

de Vries FM, Voorham J, Hak E, Denig P.
Adherence to standard-dose or low-dose statin treatment and low-density lipoprotein cholesterol response in type 2 diabetes patients.
Curr Med Res Opin. 2015;31(12):2197-206

de Vries FM, Denig P, Vegter S, Bos HJ, Postma MJ, Hak E.
Does a cardiovascular event change adherence to statin treatment in patients with type 2 diabetes? A matched cohort design.
Curr Med Res Opin. 2015;31(4):595-602

van Boven JF, van Raaij JJ, van der Galiën R, Postma MJ, van der Molen T, Dekhuijzen PN, Vegter S.
Impact of multiple-dose versus single-dose inhaler devices on COPD patients' persistence with long-acting β₂-agonists: a dispensing database analysis.
NPJ Prim Care Respir Med. 2014;24:14069

van Boven JF, de Boer PT, Postma MJ, Vegter S.

Persistence with osteoporosis medication among newly-treated osteoporotic patients.
J Bone Miner Metab. 2013;31(5):562-70

Vink NM, Klungel OH, Stolk RP, Denig P.
Comparison of various measures for assessing medication refill adherence using prescription data.
Pharmacoepidemiol Drug Saf. 2009;18(2):159-65

Biochemical adherence measurement  

Alffenaar JC, Jongedijk EM, van Winkel CAJ, Sariko M, Heysell SK, Mpagama S, Touw DJ.
A mobile microvolume UV/visible light spectrophotometer for the measurement of levofloxacin in saliva.
J Antimicrob Chemother. 2020 Oct 22:dkaa420. doi: 10.1093/jac/dkaa420.

Veenhof H, Koster RA, Junier LAT, Berger SP, Bakker SJL, Touw DJ.
Volumetric absorptive microsampling and dried blood spot microsampling vs. conventional venous sampling for tacrolimus trough concentration monitoring.
Clin Chem Lab Med. 2020;58(10):1687-1695

van der Aart-van der Beek AB, Wessels AMA, Heerspink HJL, Touw DJ.
Simple, fast and robust LC-MS/MS method for the simultaneous quantification of canagliflozin, dapagliflozin and empagliflozin in human plasma and urine.
J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Sep 1;1152:122257. doi: 10.1016/j.jchromb.2020.122257

H Veenhof, JF van Boven, A He, SP Berger, SJ Bakker, DJ Touw.
Effects, costs and implementation of monitoring kidney transplant patients’ tacrolimus levels with Dried Blood Spot sampling: a randomized controlled hybrid implementation trial
British Journal of Clinical Pharmacology 2020; 86(7):1357-1366

van den Elsen SHJ, Akkerman OW, Wessels M, Jongedijk EM, Ghimire S, van der Werf TS, Bolhuis MS, Touw DJ, Alffenaar JC.
Dose optimisation of first-line tuberculosis drugs using therapeutic drug monitoring in saliva: feasible for rifampicin, not for isoniazid.
Eur Respir J. 2020;56(4):2000803

Dijkstra A, Touw DJ, van Rheenen PF. Simple Urine Test to Evaluate Adherence to Oral 5-ASA in Teenagers With Ulcerative Colitis: Proof of Concept. 
J Pediatr Gastroenterol Nutr. 2017; 65(4):416-419

Behavioural, social, system, policy and other predictors for non-adherence  

Driever EM, Brand PLP.
Education makes people take their medication: myth or maxim?
Breathe (Sheff). 2020;16(1):190338

Alfian SD, Annisa N, Fajriansyah F, Perwitasari DA, Abdulah R, Hak E, Denig P.
Modifiable Factors Associated with Non-adherence to Antihypertensive or Antihyperlipidemic Drugs Are Dissimilar: a Multicenter Study Among Patients with Diabetes in Indonesia.
J Gen Intern Med. 2020;35(10):2897-2906

Koole T, Jaarsma ADC, Brand PLP.
Exploratory study of language paediatricians use to promote adherence to long-term controller medication in children with asthma.
Allergol Immunopathol (Madr). 2020; 48(2):116-123.

Huiskes VJB, van den Ende CHM, van Dijk L, Burger DM, van den Bemt BJF.
Association between healthcare practitioners' beliefs about statins and patients' beliefs and adherence.
Br J Clin Pharmacol. 2020 ; doi: 10.1111/bcp.14467

Driever EM, Stiggelbout AM, Brand PLP.
Shared decision making: Physicians' preferred role, usual role and their perception of its key components.
Patient Educ Couns. 2020; 103(1):77-82.

Spaans EAJM, Kleefstra N, Groenier KH, Bilo HJG, Brand PLP.
Adherence to insulin pump treatment declines with increasing age in adolescents with type 1 diabetes mellitus.
Acta Paediatr. 2020;109(1):134-139

Sianturi EI, Perwitasari DA, Islam MA, Taxis K.
The association between ethnicity, stigma, beliefs about medicines and adherence in people living with HIV in a rural area in Indonesia.
BMC Public Health. 2019;19(1):55

Wouters H, Amin DF, Taxis K, Heerdink ER, Egberts AC, Gardarsdottir H.
Associations Between Personality Traits and Adherence to Antidepressants Assessed Through Self-Report, Electronic Monitoring, and Pharmacy Dispensing Data: A Pilot Study.
J Clin Psychopharmacol. 2016; 36(5):465-71

Wouters H, Rhebergen D, Vervloet M, Egberts A, Taxis K, van Dijk L, Gardarsdottir H.
Distinct Profiles on Subjective and Objective Adherence Measures in Patients Prescribed Antidepressants.
Drugs. 2019; 79(6):647-654

Wouters H, Van Dijk L, Geers HC, Winters NA, Van Geffen EC, Stiggelbout AM, Bouvy ML. Understanding Statin Non-Adherence: Knowing Which Perceptions and Experiences Matter to Different Patients.
PLoS One. 2016;11(1):e0146272

van Boven JF, Vemer P.
Higher Adherence During Reimbursement of Pharmacological Smoking Cessation Treatments.
Nicotine Tob Res. 2016; 18(1):56-63

Wouters H, Bouvy ML, Van Geffen EC, Gardarsdottir H, Stiggelbout AM, Van Dijk L.
Antidepressants in primary care: patients' experiences, perceptions, self-efficacy beliefs, and nonadherence.
Patient Prefer Adherence. 2014; 8:179-90

Vervloet M, Spreeuwenberg P, Bouvy ML, Heerdink ER, de Bakker DH, van Dijk L.
Lazy sunday afternoons: the negative impact of interruptions in patients' daily routine on adherence to oral antidiabetic medication. A multilevel analysis of electronic monitoring data.
Eur J Clin Pharmacol. 2013; 69(8):1599-606

Clinical and economic impact of non-adherence  

Vervloet M, van Dijk L, Spreeuwenberg P, Price D, Chisholm A, Van Ganse E, Pinnock H, Rand CS, Eakin MN, Schermer T, Souverein PC, Dima AL; Respiratory Effectiveness Group's Adherence Working Group.
The Relationship Between Real-World Inhaled Corticosteroid Adherence and Asthma Outcomes: A Multilevel Approach.
J Allergy Clin Immunol Pract. 2020;8(2):626-634

RA Chimeh, F Gafar, IS Pradipta, OW Akkerman, E Hak, JW Alffenaar, JF van Boven.
Clinical and economic impact of medication non-adherence in drug-susceptible tuberculosis: systematic review
International Journal of Tuberculosis and Lung Disease 2020;24(8): 811-819

Cushen B, Sulaiman I, Greene G, MacHale E, Mokoka M, Reilly RB, Bennett K, Doyle F, van Boven JFM, Costello RW.
The Clinical Impact of Different Adherence Behaviors in Patients with Severe Chronic Obstructive Pulmonary Disease.
Am J Respir Crit Care Med. 2018;197(12):1630-1633

Dekhuijzen R, Lavorini F, Usmani OS, van Boven JFM.
Addressing the Impact and Unmet Needs of Nonadherence in Asthma and Chronic Obstructive Pulmonary Disease: Where Do We Go From Here?
J Allergy Clin Immunol Pract. 2018;6(3):785-793

van Boven JF, Chavannes NH, van der Molen T, Rutten-van Mölken MP, Postma MJ, Vegter S.
Clinical and economic impact of non-adherence in COPD: a systematic review.
Respir Med. 2014;108(1):103-13

van Boven JFM, Cushen B, Sulaiman I, Greene G, MacHale E, Mokoka MC, Doyle F, Reilly RB, Bennett K, Costello RW.
Personalising adherence-enhancing interventions using a smart inhaler in patients with COPD: an exploratory cost-effectiveness analysis.
NPJ Prim Care Respir Med. 2018;28(1):24

van Boven JF, Ryan D, Eakin MN, Canonica GW, Barot A, Foster JM; Respiratory Effectiveness Group.
Enhancing Respiratory Medication Adherence: The Role of Health Care Professionals and Cost-Effectiveness Considerations.
J Allergy Clin Immunol Pract. 2016 Sep-Oct;4(5):835-46

van Boven JF, Tommelein E, Boussery K, Mehuys E, Vegter S, Brusselle GG, Rutten-van Mölken MP, Postma MJ.
Improving inhaler adherence in patients with chronic obstructive pulmonary disease: a cost-effectiveness analysis.
Respir Res. 2014;15:66

Voorham J, Haaijer-Ruskamp FM, Wolffenbuttel BH, Stolk RP, Denig P.
Medication adherence affects treatment modifications in patients with type 2 diabetes.
Clin Ther. 2011;33(1):121-34

Hugtenburg JG, Timmers L, Elders P, Vervloet M, Van Dijk L.
Definitions, variants and causes of non-adherence: a challenge for tailored interventions.
Patient Preference and Adherence, 2013; 7, 675–682.

Vervloet M, Linn, AJ, Van Weert JCM, De Bakker DH, Bouvy ML, Van Dijk L.
The effectiveness of interventions using electronic reminders to improve adherence to chronic medication: a systematic review of the literature.
J Am Med Inform Assoc. 2012; 19(5):696-704

Adherence advocacy  

TR Zijp, PG Mol, DJ Touw, JF van Boven.
Smart medication adherence monitoring in clinical drug trials: a prerequisite for personalized medicine?
EClinicalMedicine 2019;15:3-4

JF van Boven, KR Chapman.
The hidden story of nonadherence with asthma therapy: for a few dollars more?
Journal of Allergy & Clinical Immunology: In Practice 2019; 7(7):2307-2308

JF van Boven, F Lavorini, PN Dekhuijzen, F Blasi, DB Price, G Viegi.
Urging Europe to put non-adherence to inhaled respiratory medication higher on the policy agenda: a report from the First European Congress on Adherence to Therapy.
European Respiratory Journal 2017; 49(5): 170076
Klok T, Kaptein AA, Duiverman EJ, Brand PL.
It’s the adherence stupid! (that determines asthma control in pre-school children)
European Respiratory Journal 2014; 43(3):783-91

Brand PL, Kaptein AA, Janssens LP, Klok T.
[Challenges of adolescents' adherence to therapy].
Ned Tijdschr Geneeskd. 2016;160:D502

Klok T, Kaptein AA, Brand PLP.
Non-adherence in children with asthma reviewed: The need for improvement of asthma care and medical education.
Pediatr Allergy Immunol. 2015;26(3):197-205


Digital e-Health Adherence technology  

TR Zijp, DJ Touw, JF van Boven.
User acceptability and technical robustness evaluation study of a novel smart pill bottle prototype designed to support medication adherence
Patient Preference & Adherence 2020;14:625-634