First results of the GENEVA study: Research on the genetics of food allergy in children
Food allergy is a potentially lethal disease and its prevalence is increasing in the Western world1. Furthermore, food allergy reduces quality of life in patients to a greater extent than diabetes2 and is strongly heritable3.
New avenues for Epac in inflammation and tissue remodeling in COPD
An important cytokine that is increased in COPD is interleukin-8 (IL-8). Our data indicate that Epac and PKA decrease cigarette smoke extract (CSE)-induced IL-8 release by airway smooth muscle (ASM) cells, via inhibition of NF-κB and ERK signalling, respectively. Importantly, we also observed reduced Epac1 expression in lung tissue from COPD patients6 7.
Occupational pesticide exposure increases risk for COPD
Chronic obstructive pulmonary disease (COPD) is characterized by persistent and often progressive airflow obstruction caused by and abnormal inflammatory response to noxious particles and gases. Tobacco smoking is considered to be the main risk factor for COPD, yet a substantial proportion of 15–20% of all cases has been attributed to occupational exposures1, with proportions up to 30% in never smokers2.
Targeted lung denervation for chronic obstructive pulmonary disease
We recently performed the first-in-human study investigating bronchoscopic radio-frequent ablation of the parasympathetic pulmonary nerves in patients. This new bronchoscopic minor-invasive therapy called “targeted lung denervation” (TLD) is a potential future treatment option for patients with advanced COPD.