Principal investigators

Ellen Nollen

Position Group Leader of the Laboratory of Molecular Neurobiology of Ageing
Research fields Protein aggregation, neurodegeneration, ageing, c. elegans

Research Profile

Ellen Nollen currently holds a Rosalind Franklin Fellowship at the Department of Ageing of ERIBA, where she is studying the molecular basis of Parkinson’s disease and other aging-associated neurodegenerative diseases. In July 2011 she was awarded an ERC Starting Independent Researcher Grant (€1.5 million) to work on ‘Protein damage control: regulation of toxic protein aggregation in aging-associated neurodegenerative diseases’, In November 2011 she was named as an EMBO Young Investigator. In 2007 she received an Alfred Tissières Young Investigator Award.

Ellen Nollen previously worked as a postdoctoral fellow in the Dept. of Functional Genomics, Hubrecht Laboratory, Utrecht, under Prof. Ronald Plasterk, for which she had an NWO-VENI grant, and in the Dept. of Biochemistry, Northwestern University, Evanston, USA, under Prof. Rick Morimoto, during which she was supported by NWO-Talent and EMBO long-term fellowships. She completed her PhD thesis on “Hsp70 chaperone functions in stressed cells” in 2000 under Prof. Harm Kampinga at the University of Groningen.

Contact information:

e.a.a.nollen[at]umcg.nl

Selected Publications

van der Goot AT, Zhu W, Vázquez-Manrique RP, Seinstra RI, Dettmer K, Michels H, Farina F, Krijnen J, Melki R, Buijsman RC, Ruiz Silva M, Thijssen KL, Kema IP, Neri C, Oefner PJ, Nollen EA. (2012) Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. PNAS.

Falsone SF, Meyer NH, Schrank E, Leitinger G, Pham CL, Fodero-Tavoletti MT, Holmberg M, Dulle M, Scicluna B, Gesslbauer B, Rückert HM, Wagner GE, Merle DA, Nollen EA, Kungl AJ, Hill AF, Cappai R, Zangger K. (2012) SERF protein is a direct modifier of amyloid fiber assembly. Cell reports.

Teuling E, Bourgonje A, Veenje S, Thijssen K, de Boer J, van der Velde J, Swertz M, Nollen E. (2012) Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation. PLoS currents.

Siudeja K, Srinivasan B, Xu L, Rana A, de Jong J, Nollen EA, Jackowski S, Sanford L, Hayflick S, Sibon OC. (2011) Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration. EMBO Mol Med. doi: 10.1002/emmm.201100180.

Kaminski Schierle GS, Bertoncini CW, Chan FT, van der Goot AT, Schwedler S, Skepper J, Schlachter S, van Ham T, Esposito A, Kumita JR, Nollen EA, Dobson CM, Kaminski CF. (2011) A FRET sensor for non-invasive imaging of amyloid formation in vivo. Chemphyschem. 12(3):673-80.

van Ham TJ, Holmberg MA, van der Goot AT, Teuling E, Garcia-Arencibia M, Kim HE, Du D, Thijssen KL, Wiersma M, Burggraaff R, van Bergeijk P, van Rheenen J, Jerre van Veluw G, Hofstra RM, Rubinsztein DC, Nollen EA. (2010) Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity. Cell.

van Ham TJ, Esposito A, Kumita JR, Hsu ST, Kaminski Schierle GS, Kaminski CF, Dobson CM, Nollen EA, Bertoncini CW. (2010) Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation. Mol. Biol. 22;395(3):627-42.

Roodveldt C, Bertoncini CW, Andersson A, van der Goot AT, Hsu ST, Fernández-Montesinos R, de Jong J, van Ham TJ, Nollen EA, Pozo D, Christodoulou J, Dobson CM. (2009) Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO J. 28(23):3758-70.

van Ham TJ, Breitling R, Swertz MA, Nollen EA. (2009) Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms. EMBO molecular medicine.

van Ham TJ, Thijssen KL, Breitling R, Hofstra RM, Plasterk RH, Nollen EA. (2008) C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS genetics.

van Haaften G, Vastenhouw NL, Nollen EA, Plasterk RH, Tijsterman M. (2004) Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proc. Natl. Acad. Sci. USA 101(35):12992-6.

Nollen EA, Garcia SM, van Haaften G, Kim S, Chavez A, Morimoto RI, Plasterk RH. (2004) Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. PNAS.

Kim S, Nollen EA, Kitagawa K, Bindokas VP, Morimoto RI. (2002) Polyglutamine protein aggregates are dynamic. Nature cell biology.

Nollen EA, Morimoto RI. (2002) Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. J. Cell Sci. 115:2809-16.

Nollen EA, Salomons FA, Brunsting JF, van der Want JJ, Sibon OC, Kampinga HH. (2001) Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection. Research Highlights, Nature Reviews Molecular Cell Biology, 2: 786-786).

Nollen EA, Kabakov AE, Brunsting JF, Kanon B, Höhfeld J, Kampinga HH. (2001) Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1. The Journal of biological chemistry.

Nollen EA, Brunsting JF, Song J, Kampinga HH, Morimoto RI.. (2000) Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Mol. Cell. Biol., 20: 1083-1088.

van der Leij FR, Roelofsen H, Niezen-Koning KE, Nollen EA, Kuipers JR. (1999) Confocal laser scanning microscopy of human skin fibroblasts showing transient expression of a green fluorescent carnitine palmitoyltransferase 1 fusion protein. Adv. Exp. Med. Biol., 466:111-5.

Nollen EA, Brunsting JF, Roelofsen H, Weber LA, Kampinga HH. (1999) In vivo chaperone activity of heat shock protein 70 and thermotolerance. Molecular and cellular biology.

Martens DE, Nollen EA, Hardeveld M, van der Velden-de Groot CA, de Gooijer CD, Beuvery EC, Tramper J. (1996) Death rate in a small air-lift loop reactor of vero cells grown on solid microcarriers and in macroporous microcarriers. Cytotechnol., 23: 61-75.

Peters SA, Verver J, Nollen EA, van Lent JW, Wellink J, van Kammen A. (1994) The NTP-binding motif in cowpea mosaic virus B polyprotein is essential for viral replication. The Journal of general virology.

Sponsors / Funding

The research of Ellen Nollen is powered by: 

Het Ubbo Emmius Fonds
 
 
 
 
 

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